Anna appears in Dean's head as he dreams about a devil and angel stripping for him. Anna says she has been in a heavenly prison after Castiel turned her in to the angels. She explains she managed to break away from her captors. She asks him to meet her at a warehouse later. Dean wakes up from his dream.

Anna arrives at a warehouse and calls out to Dean, but Castiel appears instead. Castiel figures Anna was released to do Heaven's bidding. Castiel tells him no one can escape the prison. He sees that Anna has a knife that can only be used to kill humans. She admits that she thinks Sam has to die since he is Lucifer's true vessel. She says Lucifer's plan will fall apart if she scatters Sam's body throughout the universe. Castiel says she can't let her kill Sam since he is his friend. Anna disappears and goes back in time. A couple finds her passed out with a bloody nose on the hood of their car.

Castiel tells the brothers that Anna wants to kill Sam. Sam wonders if Anna's plan will work, but Castiel says it won't. Castiel says they should kill Anna first. He casts a spell to look for Anna, then discovers she went back in time. Castiel says Anna is in 1978. He figures Anna wants to kill their parents before Sam was born. He explains it is difficult to travel back in time, especially when taking them.