From fox.com:
"The average person tells three lies in ten minutes of conversation.

DR. CAL LIGHTMAN (Tim Roth, "The Incredible Hulk," "Reservoir Dogs") can detect the truth by analyzing a person's face, body, voice and speech. When someone shrugs his shoulder, rotates his hand or raises his lower lip, Lightman knows he's lying. By analyzing facial expressions, he can read feelings - from hidden resentment to sexual attraction to jealousy. But as Lightman well knows, his scientific ability is both a blessing and a curse in his personal life, where family and friends deceive each other as readily as criminals and strangers do. Lightman is the world's leading deception expert, a scientist who studies facial expressions and involuntary body language to discover not only if you are lying but why.

From writer Samuel Baum ("The Evidence") and the executive producers of 24 and "Arrested Development" comes LIE TO ME, a compelling new drama series inspired by the scientific discoveries of Dr. Paul Ekman, a real-life specialist who can read clues embedded in the human face, body and voice to expose both the truth and lies in criminal investigations.

Lightman heads a team of experts at The Lightman Group who assist federal law enforcement, government agencies and local police with their most difficult cases. DR. GILLIAN FOSTER (Kelli Williams, "The Practice") is a gifted psychologist and Lightman's professional partner who brings balance to the partnership by looking at the bigger picture while Lightman focuses on the details. He needs her guidance and insight into human behavior, whether he knows it or not. ELI LOKER (Brendan Hines, TERMINATOR: THE SARAH CONNOR CHRONICLES) is Lightman's lead researcher, who is so uncomfortable with the human tendency to lie that he's decided to practice what he calls "radical honesty." He says everything on his mind at all times and often pays the price. RIA TORRES (Monica Raymund, "Law and Order: SVU") is the newest member of the agency, and one of the few "naturals" in the field of deception detection. She has a raw, untrained ability to read people that makes her a force to be reckoned with."

Cal Lightman and his team try to figure out who killed a teacher.

Gillian and Eli investigate a bribe while Cal and Ria look into a rape case.

Cal and Ria investigate the death of a school girl while Gillian and Eli look into a pilot's role in a plane crash.

Cal and the team work to find a potential assassin of a South Korean ambassador.

Cal and Ria try to figure out if a murderer has truly reformed while Gillian and Eli investigate the mysterious death of a fireman.

Cal and Gillian look for a missing child while Eli and Ria look into the life of a refugee.

An old friend of Cal asks for his help with investigating a drug company while Gillian and Eli help negotiate the release of prisoners in Yemen.

Cal and Ria look into a series of suicides committed by young Indian women while Gillian and Eli investigate a case of suspected SEC fraud.

Cal and Gillian assist FEMA with a rescue operation at a collapsed construction site while Ria and Eli interview the girlfriend of a billionaire.

Cal teams up with his ex-wife to investigate an arson while Ria and Gillian look into the murder of a rap producer.

Cal's investigation of a shooting leads to the uncovering of a terrorist plot.

Cal works with the FBI to stop a copycat serial rapist who blinds his victims.

The team works to solve terrorist bombings in the DC area, but Gillian is distracted by marital problems and Ria is worried that her boyfriend in the Secret Service is in danger.

Cal investigates a woman with multiple personalities in which one of them may be a killer. Ria vets a Supreme Court nominee and finds that he is hiding a personal relationship with a woman involved in a case he ruled on.

Zoe hires Cal to investigate whether or not her client knowingly slept with an underage girl. Gillian and Eli look into a religious cult to see if it is legitimate.

Cal goes on vacation, but finds that people everywhere are in need of his skills. Meanwhile, Gillian works with Cal's rival during an investigation of contaminated blood.

Cal is taken hostage by a man who forces the institute to prove he didn't kill his wife.

An old friend of Cal leads him in to doing business with shady characters. Meanwhile, the rest of the team investigate a potential school threat.

After an assassination of a crucial witness against a mob boss, Ben is forced to relive the sins he committed while working undercover.

Cal and Gillian help a teenager find his real parents. Meanwhile, Ria and Eli work on easing the blame placed on a retail store for a stampede that occurred during Black Friday.

Cal is sent to Afghanistan to interrogate an American turned Taliban about the location of two captured U.S. soldiers. Meanwhile, Emily sets up a party at the institute.

Cal and the team travels to Vegas to investigate the disappearance of a poker player. Back at the institute, Ria and Eli analyze a date that Eli took out.

After a bomb threat is called by a farmer parked in front of a federal building, Cal goes in to investigate while watching over a group of kids who are touring the institute.