From cbs.com:
"Melinda Gordon (Jennifer Love Hewitt) has a gift - she can communicate with earthbound spirits or ghosts who cling to the living because they have unfinished business in our world preventing them from "crossing over" or going into the light. Inspired in part by the work of famed medium James Van Praagh and of Mary Ann Winkowski, a real-life communicator with earth bound spirits, GHOST WHISPERER explores the spiritual side of life and death. Melinda navigates between the dead and the living with her sometimes chilling, sometimes heart-rending and sometimes amusing actions as an intermediary between the ghosts and those they haunt. Although she is very good at being an intermediary she never publicizes this gift instead is known around town as a newlywed and the owner of the successful antiques store, Same As it Never Was.

Firefighter Jim Clancy (David Conrad), Melinda's husband, knows that being an intermediary between the living and dead can take an emotional toll on his wife and worries that he might not be able to protect her as well as he would like. Melinda has also recently revealed her gift to new friend and employee, Delia Banks (Camryn Manheim), a single mom of teenager Ned Banks (Christoph Sanders). Melinda fears what the consequences might be of drawing Delia into this unconventional world, as Delia, unlike her son Ned, is a bit skeptical of Melinda's gift - although she loves Melinda unconditionally as a friend. Melinda has also shared her secret with Eli James (Jamie Kennedy), a psychology professor at Rockland University, who is a unique individual - he has the gift of hearing ghosts, but not seeing them. For her part, Melinda accepts her unique abilities as a blessing and sometime curse, but always helps her clients, alive or dead, find emotional closure."

A near death experience unlocks a man's ability to hear ghosts. He is haunted by a fire starting former patient. Does she want revenge or something else?

A ghost haunts Melinda's high school classmates and they ask for her help.

A ghost uses the computer to communicate with his daughter and Melinda.

Melinda and Jim board a luxury cruise for some romantic time alone, but the ship turns out to be haunted and the ghosts seek Melinda's help.

A teenager suddenly drops dead, revealing a mystery that stems from her birth.

Jim's friend Tricia prepares for her wedding to Hunter and everybody heads up to a cabin resort for the ceremony. Tricia's daughter Natalie makes a new friend only she and Melinda can see and Tricia is forced to play a game to avoid disaster.

After Jim's death, Melinda is unable to see him or any other ghosts, but Jim can still see her.

Sam, the man who's body Jim jumped into, wakes up in the hospital and finds Melinda there with him. He has no memories and looks to Melinda for help.

Melinda sees a ghost at Sam's work site and has to do her job while keeping it hidden from Sam, meanwhile, Sam learns a little more about his past.

Melinda must help a ghost come to terms with her marriage so that she can cross over.

Delia is trying to sell a house, but she needs Melinda's help to get rid of the ghost living there first and Sam finds out more about his past.

Melinda joins Sam on his trip to find Nicole and makes some new acquaintances along the way.

Melinda becomes concerned that Nicole's prolonged visit may cause Sam to remember his old life. Meanwhile, she discovers a group of vengeful ghosts at a local lake where a mortician has been secretly dumping bodies.

Melinda takes Sam to a school dance and is approached by the ghost of a student's mother.

A girl goes missing during a hazing for a sorority and Melinda joins the search.

Melinda sees a 'professional' paranormal investigator outside her friend's house and Sam tells her he doesn't believe in ghosts.

Sam watches Melinda as she helps a ghost who is haunting a kindergarten class.

Dr. Byrd brings Melinda to a man who can help Jim recover his past.

Jim comes to terms with living as Sam and Eli tries to help his neighbor deal with a ghost. Hilary Duff guest stars.

A ghost shows up in connection with a soap opera that is being filmed at Melinda's shop.

Melinda is confronted by ghosts living inside a dollhouse.

While trying to plan her and Jim's wedding, Melinda is distracted by a young woman who needs her to help get vampires to leave her alone.

Melinda worries about protecting her baby after she is visited by a ghost.

Melinda gives birth to her child, then time jumps forward five years as Melinda tries to figure out why a ghost woman is stalking her family.

Ned asks for Miranda's help to try to figure out why a ghost is terrorizing the town through a chain email. Meanwhile, Miranda is haunted by some disturbing dreams.

Eli must try to uncover the secrets of his parent's past in order to help them cross over into the light.

Two teens break into the morgue, discover it is haunted, and Melinda investigates.

Eli takes on a wealthy new client and Melinda notices Aiden is developing some odd behaviors.

Melinda is concerned about Aiden's new friends as she tries to solve a Halloween themed haunting.

Jim thinks he is being haunted by one of his patients, but learns that it is actually his professor that the ghost is after.

Melinda meets a former real estate agent turned ghost who suspects his wife killed him. Meanwhile, Jim discovers that Aiden can perform magic tricks with the help of ghosts.

Jim and Melinda frantically search for Aiden when Julia takes him away.

Melinda investigates the death of a teenage boy she suspects was involved with the daughter of a police officer.

A ghost haunts Ned at a radio station. Melinda investigates and learns the ghost is seeking revenge for his broken heart.

Melinda investigates a ghost that is haunting a new family who has a daughter that Ned is getting involved with.

A gift that Ned gives to one of his professors summons a ghost who they suspect is trying to bring romance to her life.