A trucker turns up his music after he hears the locks to the back area rattle. A man speeds back home while he is on the phone with his wife who he thinks is cheating on him. The driver tells the people in his back to shut up. The man drops his phone and swerves as he tries to retrieve it. After he looks up, he crashes into the truck.

The CSI team examines the scene. Flack reports that this is the driver's third and last DUI since he is now dead. Mac figures the truck driver lost control, went through the median, and drove on the wrong side of the road. Flack reports the trucker driver fled the scene. He brings Stella and Mac around back and shows them a dead woman who was stuffed in a oil barrel.

After Sheldon arrives at the scene, they figure the victim has been dead for 36 to 48 hours. Stella notices that there is no blood in the barrel which indicates the victim was killed somewhere else. The body is brought back to the lab where Sid examines it and finds a cross incision on her abdomen.

At the scene, Lindsey and Danny test a hulu doll on the dash and finds traces of blood. They figure that either the driver or a passenger was injured. Flack tells Mac that the truck was leased by a person who used phony identification. Mac sees that there is a portable outhouse in the truck compartment. They figure a woman was locked inside. Lindsey says there is no sign of a second body.