As a woman drives, her Nissan gets a flat tire. Even though her car sparks, she continues to drive.

The woman's mother reports that her daughter is missing. Horatio asks the woman if he can help her. The woman says her daughter is named Ashley Tanner. She plays him a message from her daughter and says she was supposed to meet her yesterday. She says her daughter was driving a Nissan to meet her in Miami.

Later, the police discover Ashley's car on the side of the road. Calleigh tells Horatio they found blood at the scene. Calleigh tells Jesse that she believes Ashley drove over a spike strip. They find blood splattering on the ground and figure it was caused by blunt force trauma. Jesse finds a parking stub for Town South Hotel which they suspect is where she had her tire popped. They find signs of struggle and suspect Ashley was abducted.

At the lab, Jesse tests different objects to see if it creates a blood splatter pattern that matches what was found at the scene. Walter goes to the hotel and asks a valet if he has seen Ashley. He shows him Ashley's car and he remembers when Ashley drove over a spike strip. Boa Vista and Ryan learn that Ashley stayed at a hotel room paid for by a man named Jimmy Burris. Out by the pool, Jimmy flirts with a woman. Jimmy tells Ryan that Ashley was one of his new models.

After Jimmy learns that Ashley is missing, they go to her room. Ryan and Boa Vista see it is littered with empty booze bottles, a cigar and room service plates. Boa Vista finds a plastic bag she suspects was used for erotic asphyxiation. Jimmy says Ashley was a freak and shows them a video of Ashley while she was in bed.